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ea0026p500 | Bone/calcium/Vitamin D | ECE2011

Single nucleotide polymorphisms of the OPG/RANKL system genes in primary hyperparathyroidism and their relationship with bone mineral density

Piedra M , Garcia-Unzueta M T , Berja A , Riancho J A , Valero C , Paule B , Lavin B A , Amado J A

Background: Primary hyperparathyroidism (PHPT) affects mainly cortical bone. It is thought that PTH indirectly regulates the activity of osteoclasts by means of the osteoprotegerin/ligand of the receptor activator of nuclear factor-κβ (OPG/RANKL) system. Several studies have confirmed that OPG and RANKL loci are determinants of bone mineral density (BMD) in the general population. The aim of this study is to analyze the relationship between fractures and BMD and the ...

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ea0026p512 | Bone/calcium/Vitamin D | ECE2011

rs219780 SNP of CLDN14 gene is not associated with kidney stones, fractures or bone mineral density in primary hyperparathyroidism

Piedra M , Berja A , Garcia-Unzueta M T , Gutierrez-Hierro M T , Garcia-Llama N , Renteria C , Lavin B A , Amado J A

Background: CLDN14 gene encodes a protein involved in regulation of paracellular permeability or ion transport at epithelial tight junctions as in the nephron. C allele of the rs219780 SNP of CLDN14 gene has been associated with high levels of PTH and with low bone mineral density (BMD) in women. Our aim is to study the relationship between rs219780 SNP of CLDN14 and fractures, renal lithiasis and bone mineral density in patients with primary hyperparathyr...

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Endocrine Abstracts

Single nucleotide polymorphisms of the OPG/RANKL system genes in primary hyperparathyroidism and their relationship with bone mineral density

rs219780 SNP of CLDN14 gene is not associated with kidney stones, fractures or bone mineral density in primary hyperparathyroidism

BiosciAbstracts